CARMeN

The CARMeN (Cancer NMR) project through a consortium between the University Hospitals of Strasbourg, Strasbourg University, CNRS and Bruker BioSpin, was certified on 20 December 2006 by the Competitiveness Cluster “Therapeutic Innovations” of the Region Alsace and funded up to 2.7 million euros.

This project allowed us to create a metabolomics database in several types of cancers in order to :

  1. Establish an inventory of metabolites in each subtype of tumor
  2. Assess the intrinsic heterogeneity of tumors
  3. Search for predictive metabolic fingerprints of poor prognosis and/or response to therapy

We, like many other groups, believe that the strategy of using the phenotype, in other terms the metabolic footprint of tumors as evaluation criteria is a very promising strategy for the identification of high-risk cancers and the development of personalized treatments.

Project certification: December 2006
Project funding: September 2007
Equipment installation: November 2007
Starting operation: January 2008

 

 

  • Brain Tumors, Pr F. PROUST, Pr N. ENTZ-WERLE, Dr B. LHERMITTE, Pr M-P CHENARD, Pr N. ENTZ-WERLE (Hôpitaux Universitaires de Strasbourg), Pr G. NOËL (Centre Paul Strauss, Strasbourg)
  • Pancreatic cancers, Dr F. FAITOT, Pr Ph. BACHELLIER, Dr G. AVEROUS (University Hospitals of Strasbourg)
  • Adrenal gland cancers, Pr Ph. BACHELLIER, Pr B. GOICHOT (University Hospitals of Strasbourg) Pr D. TAIEB (University Hospitals of Marseille),
  • Neuroendocrine tumors, Pr Ph. BACHELLIER, Pr B. GOICHOT (University Hospitals of Strasbourg), Pr G. PONCET (University Hospital of Lyon)
  • Liver cancer, Dr F. FAITOT, Pr Ph. BACHELLIER (University Hospitals of Strasbourg)
  • Parathyroid glands adenoma, L. BRUNAUD (University Hospital of Nancy), F. SEBAG (University Hospital of Marseille)
  • Tumoral cells treated by Mitotane, Dr M. LOMBES, (University of Paris-Sud/ INSERM)
  • Ovarian cancers, Dr G. AVEROUS (University Hospitals of Strasbourg)
  • Breast cancer, Pr C. MATHELIN, Pr J.-P. BELLOCQ (University Hospitals of Strasbourg)
  • Kidney cancer, Pr H. LANG (University Hospitals of Strasbourg)
  • Neuroblastoma, Pr P. LUTZ (University Hospitals of Strasbourg)
  • Colon cancer, Pr C. BRIGAND, Dr A. NEUVILLE (University Hospitals of Strasbourg)

 

Partners of the project:

hopitaux-universitaires  unistra    cnrs  bruker  canceropole innovation therapeutique alsace  conseil-generalstrasbourg-cusoseo

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